Pfizer R&D and Process Development Facility

Chesterfield, MO
Owner Pfizer
Architect Forum Studio
Construction Manager Clayco
Design Build Mechanical icon Mechanical

icon Mechanical is a proud member of the mechanical design-build/assist team for Pfizer’s new state-of-the-art facility—a 295,000 square foot research and development space. More than 450 employees (currently working at multiple locations in the St. Louis area) will call the site home, with the plans of hiring an additional 80 employees over the coming years. The dual-purpose structure will be comprised of laboratory and office space, housing Pfizer’s BioTherapeutics Pharmaceutical Science group and enabling partners. The floor plan will provide scientific casework and utility hookups, flexible laboratory layouts, open office and collaboration spaces and increased conferencing technologies where researchers can collaborate. 

The Development Lab is a four-story building, plus a mechanical penthouse. Level 1 includes the Lobby and Amenity Spaces (including dining), the Pilot Plant, Solution Prep, Warehouse, Support Areas and Loading Dock. Levels 2-4 include the laboratories, office areas, interaction spaces, as well as a Cell Bank Clean Room ISO 7 and an OEB 5 lab space.

To date, icon Mechanical plans for the design, prefabrication and installation of the following components to the mechanical penthouse:

  • Central Utility Plant including 3,000 Tons of Cooling Capacity and (4) 1,000 Ton Chillers 
  • 24,000 MBH of Hot Water Boilers
  • Steam Boiler System with 600 HP Output with N+1 Redundancy for Process Heating
  • Pre-piped Core Wall Benches
  • Pilot Plant Vaccines (All Piping and Mechanical for the Pilot Plant by icon)
  • Cell Bank Clean Room ISO 7
  • 70 Air Changes per Hour
  • High Purity Water
  • Clean-in-Place (CIP) System
  • Medium and Low-Pressure Steam Bioreactors
  • 12 Air Handling Units (AHU) – Each Average 35,000 CFM  

icon Mechanical’s role on projects of this scale and technical detail requires a complete understanding of how every component of the building will operate. From the materials of the exterior skin to the light fixture selection has significant impact on how we design and select the right equipment. Through many collaborative meetings with all the team members, we were able to develop the best systems—early on in the process. It is through this form of Value Engineering that we are able to deliver improved constructability, better system selections, more efficient design and better market pricing.

icon’s fabrication shops have been working since earlier this spring (prior to the ground breaking), to complete the piping components for the facility. See our photos for additional details on our progress thus far.



Capabilities Used